A few of my friends spoke to me quite some weeks back to request if I could highlight some issues on breast cancer.
I therefore approached someone I know in the specific field and that someone is OG Dr Humairah Samad Cheung (K Mai), Director , IIUM Breast Centre, Kuantan. She has kindly sent the article to me.
Here it is....
Introduction
Many weeks ago Ruby asked whether I would write something on the subject of breast cancer in Malaysian women. The demise three days ago of our First lady, Datin Seri Endon bte Mahmood, after a brave battle with breast cancer, made the request that much more pressing
Breast Cancer Statistics in Malaysia
Breast cancer is common, and no woman is immune to the disease. It is in fact the commonest cancer amongst women worldwide. In Malaysia, the 2002 statistics are that 4337 women were newly diagnosed with it. It is not only the commonest cancer amongst Malaysian women, but the commonest cause of cancer deaths amongst us. Cancer of the cervix trails behind it in second place. There is evidence that it is increasing in incidence.
It is estimated that a woman in Malaysia has a 1 in 19 chance of getting breast cancer in her lifetime. There is a racial difference seen in its incidence, with Chinese women having a 1 in 14 chance, Indian women a 1 in 15 chance, and Malay women a 1 in 24 chance of developing the cancer. This may seem low when compared to American women in whom the chance of developing it is 1 in 7.
The Age Standardised Incidence Rate (ASR) in American white women, British women and Malaysian Chinese women are 91 per 100,000, 69 per 100,000 and 70 per 100,000 respectively. Amongst Malay women this is 42 per 100,000.
IN Malaysia, the cancer is commonest amongst women aged 50-59 years. However there are many cases of younger women who are affected, and the consequences on a young family may be greater.
Why are we hearing much more of breast cancer now? Why is breast cancer so common?
The direct cause is unclear; however many factors have been noted to be associated with increasing risk of developing breast cancer. It is commoner with increasing age, and this may be related to damage to our genetic material. When a woman has a first degree relative (mother, sister, daughter) affected by breast cancer her risks multiplies 9 times. There are hereditary breast cancers in women who have the BRCA1 and BRCA 2 genes.
Life style factors are important too. With changes in women’s lifestyles from the time of our mothers, families have become smaller, and women tend to postpone child-bearing to a later age. There is also a lesser tendency to breast-feed amongst career women. The more a woman breast feeds the greater the protective effect against breast cancer. Other protective factors include having periods later, and menopause earlier in life. Other lifestyle factors include diet, exercise, and the level of stress. These factors are given in Table 1
Table 1: Risk Factors for Breast Cancer
| 1 | Being female | <1%> |
| 2 | Age | Its incidence increases with increasing age. In Malaysia it is commonest in the 50-59 years age group |
| 3 | Genes | Increased risk in those with a positive family history, especially if the person affected is young. Gene traits linked to breast cancer include BRCA1 and BRCA2 genes |
| 4 | Hormones | Increased risk in women with early onset of menstruation and late menopause, in those who are childless or with delayed child-bearing beyond age 30 years. Breast feeding protects against breast cancer |
| 5 | Diet | Increased fat intake is associated with higher risk |
| 6 | Other life-style factors | Lack of exercise, obesity and stressful lives are associated with increased risk |
| 7 | Carcinogens | In food, and in the environment, including exposure to radiation and cigarette smoke are associated with increased risk. |
| 8 | Biopsy | Results such as atypical ductal hyperplasia predispose to higher risk |
What can protect us from breast cancer?
Protection is never 100%, as there are many things we can’t change; at least not for the time being. These include our genetic constitution and the family into which we are born!
However, there are also some things we can change. These include developing a healthy life style, and becoming more pro-active in maintaining and preserving our health. Regular exercise and an active life style, avoiding over-indulgence in rich food, and maintaining a steady body weight and body mass index and avoiding obesity are some ways by which cancer and other disease may be kept at bay.
Being pro-active in health matters include having regular check-ups, and early consultation over bodily complaints or developments which seem unusual. Many health conscious women, (and in my experience Chinese women are in the fore-front here) go for regular check-ups and screening tests, and then spend time quizzing their doctors over the results of blood and other tests!
In the case of breast cancer, the best and most sensitive way of checking for its early signs in by performing a mammogram. It is recommended that a baseline mammogram be performed when a woman turns 40. From that age on she should have the examination at least once in two years. Mammogram does not prevent a woman from developing breast cancer. It merely detects early signs of cancer, in the form of a small breast lump or the presence of minute calcifications within a small area of the breast, which is referred to as “clustered microcalcifications”. Not all calcifications in the breast is associated with or caused by cancer. And that is why you should insist that your mammogram be read by a radiologist with sufficient experience in reading mammograms!
Other methods are available. These include breast self examinations (BSE), physical examination by your general practitioner of family physician, Breast Ultrasound, and Magnetic Resonance Imaging.
Women are now increasingly being taught, and learning how to perform BSE. Not all clinics offer this service, and medical practitioners should teach and encourage women to do this. BSE should be performed in the first 10 days after the period, when the breasts are not tender or swollen. For many this may be the first method by which a lump is discovered in the breast. It is important not to panic at this stage, because the majority of breast lumps (~80%) are in fact not cancer. However it is wise to seek medical help and ask to be referred for a mammogram, so that the appropriate advice and management can be offered. Other signs that one must look out for is a nipple discharge, especially if it is frankly bloody, or blood-stained. A skin rash or redness in the nipple or areolar area, a change in the “feel” of one breast, (such as hardening or firming) may be early signs too. Sometimes a dimple in the skin or a nipple that is noted to be pulled inwards may be other signs.
More on Mammograms
Many women are fearful of having a mammogram because of preconceived idea that it is painful. However modern equipment are more friendly in their design, and breast compression during mammography is shortened and automatically relieved as soon as the exposure is made.
Mammogram is advised after age 40 years in all women, and thereafter once every 1-2 years. Women with a family history of breast cancer are advised to have a baseline mammogram at 35 years. Mammography is more sensitive in cancer detection in older women because the breasts are fatty and less glandular; this gives a dark background and small cancers are best displayed and detected. In young women the breasts are glandular and the cancer detection rate is lower because small cancers may be hidden within the higher density of the glandular breasts. In this situation, the attending radiologist will perform an ultrasound, which complements the mammography in this clinical situation.
Do note that for the above reasons, mammography can miss cancers. Some studies have shown that this may occur in 5-15% cases, even in skilled hands. Mammography should always be performed at places with skilled and trained mammographers and radiologists for optimal technique and interpretation.The performance of Quality assurance (QA) tests are essential in mammography centres.
In developed countries women above 50 are invited to undergo mammography because it has been shown that early detection by mammography has indeed saved lives. Women are also protected by the Mammography Act and accreditation of mammography centres, and this is yet in the infantile stage in Malaysia.
What happens if the investigations (e.g. mammography) show a lump that is suspicious for cancer?
Further investigations are required in this situation. In a one-stop centre sampling of the lump is arranged as soon as it can be performed, often in the same day so that diagnosis is not delayed. This will take the form of a core biopsy where an elongated 1-2cm of tissue is removed form the lump and sent to the Pathology Laboratory where the Pathologist will read and interpret the cellular components which will confirm cancer or otherwise. This is the best and most accurate method of making the diagnosis.
Sometimes only an aspirate (Fine Needle Aspiration Cytology; FNAC) is taken from the lump, especially if the pathologist reading it is experienced in cytology (interpretation of the cell type from the aspirated material smeared on a slide). The attending radiologist or physician will advise accordingly. These procedures will require your written consent, following your being fully informed of the procedures.
The above procedures are best performed under image guidance using either an X-Ray technique called stereotaxis, or under ultrasound-guidance. This will ensure that the sampling has been accurate, with the needle placed within the lump. There is a possibility that the lump can be missed if it is done blind (guided by feel with the hands only), especially if the lump is small, and less than 2 cms.
A woman with a lump that she can feel with her bare hands should insist on mammography and/or breast ultrasound to be performed. In some women the breasts can be normally lumpy, due to the arrangement of glandular tissue and fat lobules within it. This may cause difficulty for the physician who only performs a physical examination manually.
Can one survive breast cancer?
The simple answer to this is yes! This is provided that the cancer is diagnosed and treated early.
Once diagnosed the cancer is staged form Stage 1 to Stage 4, based of the size of the cancer and whether it has spread to other sites known to commonly be involved by its spread. Stage 1 cancer is when the cancer is less than 2 cm in diameter, and confined to one site in the breast. Women with stage1 breast cancer have an 80% chance of survival 5 years after treatment. However if the cancer is diagnosed in Stage 4 when it has already spread to distant sites such as bone, liver or brain, the expected survival at 5 years is much reduced.
The “survivors’ pool” of women who have had breast cancer and survived it is growing, and in many places these women have organised themselves to become a group that is committed and effective in helping other women newly diagnosed with the cancer. Some are registered as NGOs (Non-Governmental Organisations) and other formal organisations. They work as voluntary groups, and work hand-in-hand with medical practitioners (mainly surgeons, radiologists and oncologists) to create a higher state of breast cancer awareness.
Some Malaysian women (especially Malay women) feel that getting breast cancer somehow confers a stigma on oneself, and will keep the cancer a secret from family and friends. My own personal opinion that the burden of breast cancer can be lessened if one shares it with loved ones, who can lend a shoulder to cry on. It is a natural response to become depressed initially, and to feel that “this cannot be happening to me”, and to feel that life is unfair. However the earlier one gets out of this denial stage and get on with the “complete” treatment, the better, because the best of life may still be beyond the cancer.
Accept the fact that no woman is immune from breast cancer. And see it the way I do; even though that it may mean losing an asset, it is after all a superficial appendage, (unlike say, cancer of the ovary or lung), and surgical removal does not require opening the abdomen or pelvis or rib-cage. In the same way that one can wear a wig when you lose your hair, there are breast prostheses and special underwear that can make you feel like a whole woman again should you have one breast removed. One should always look on the bright side, as a positive mental outlook is half the battle won!
So while we grieve with the family of our beloved Pak Lah, let us remember AllahYarham Datin Seri Endon who went about her life’s work courageously, and gave so much of herself, even while it was widely known that she was undergoing treatment for breast cancer. The simple and brave message that she left behind must surely be for us not to be defeated by breast cancer – that life must go on despite it.
Humairah Samad Cheung
Director, IIUM Breast Centre, Kuantan
Thank you K Mai, for your sheer effort and dedication.
Touched,
Ruby Ahmad.































